Crataegus monogyna and Centella asiatica Extracts as Inhibitors of Cathepsin S

Cathepsin cysteine proteases such as cathepsin S are responsible for the unfavorable and irreversible dysregulation of extracellular matrix (ECM) proteolysis found in cardiomyopathy, heart valve diseases atherosclerosis. plays a central role ECM remodeling, which has been implicated development progression cardiovascular diseases. The current study aimed to evaluate aqueous ethanol extracts berries Crataegus monogyna leaves Centella asiatica inhibition activity using an vitro fluorescent assay. Dried ground dried were used prepare organic extracts. A fluorometric enzyme assay was by plant produced maximum 6% 9.6% respectively, at 200 μg/ml. extract 14%, occurring with 100 μg/ml concentration. concentration-dependent all concentrations, 71.7% obtained highest concentration This demonstrates that crucial could serve viable source isolation inhibitors.